[ association between dietary fat intake and pancreatic cancer risk: a large prospective study]

Pancreatic cancer [PC] is classified as one of the most deadly cancers. Since the role of diet in modifying the effects of known risk factors of PC has been well established, exploring the dietary intakes in relation to the etiology of PC can be useful for elucidating the mechanisms of the disease progression

Materials and Methods: This study was conducted within the Golestan prospective cohort study. The estimated intake of total fat and various dietary fat sources was calculated using a validated semi-quantitative food frequency questionnaire. The relationship between these dietary intakes and risk of PC was examined using Cox Regression and hazard ratio [HR] with 95% confidence interval [CI 95%] was reported

Results: During 383,630 person-years follow-up and after excluding subjects with incomplete baseline information, a total of 48,676 adults were studied. Until October 30, 2014, 54 cases of PC were confirmed by medical professionals, based on the medical records and the exact cause of death using the criteria of the International Statistical Classification of Diseases and Related Health Problems 10 [ICD10]. After adjusting for potential confounders we did not observe any statistically significant relationship between the intake of total fat and various dietary fat sources and risk of PC. There was only a significant positive association between the risk of PC and daily intake of butter, cream, and solid vegetable oil in the age-adjusted regression models [HR=2.10; 95% CI=1.04-4.21; P for trend=0.03]. However, this relationship was not remained significant anymore in the fully adjusted models

Conclusion: Based on the results of the current research, after taking into account all of the potential confounding factors, dietary intake of total fat as well as various dietary fat sources had no significant association with the risk of PC. However, it is likely that consuming substantially less saturated and trans fat sources such as dairy fats as well as solid vegetable oils may be beneficial to reduce the risk of this cancer

[Higher intake of dietary fiber, but not fruits or vegetables is associated with lower risk of pancreatic cancer: a large prospective study]

Background: pancreatic cancer [PC] is classed as the 7th leading cause of cancer-related death in the world. Previous evidence indicates that hyperglycemia, insulin resistance, diabetes, and obesity are implicated in pancreatic carcinogenesis. Thus, evaluation of the dietary intakes in the etiology of PC can be useful to identify the risk factors of the disease

Materials and Methods: we examined the association between total intake of fruits, vegetables, and dietary fiber and the risk of PC in 50,045 participants aged 40-75 years within the Golestan Cohort Study. Dietary data were collected using a validated semi-quantitative food-frequency questionnaire, which was administered at baseline. Cox proportional hazards models were used to estimate multivariate hazard ratio with 95% confidence interval

Results: during 383,630 person-years of follow-up and after excluding the participants with incomplete baseline information, a total of 48,676 adults were evaluated. Until October 30, 2014, 54 cases of PC were confirmed based on the exact cause of death using ICD10 criteria. After considering all potential confounding factors, there was only a statistically significant inverse association between the risk of PC for the highest tertile of daily fiber intake compared with the lowest tertile [HR=0.41; 95% CI= 0.15-1.05; P for trend= 0.05]. However, the relationship between fruits and vegetables and PC risk was not statistically significant

Conclusion: in summary, based on the findings of this study, increased dietary fiber may reduce the risk of PC. This result highlights the importance of a diet rich in fiber in order to prevent PC progression. Finally, given the limited number of studies in this field and inconclusive results, there is still a need for new prospective studies with long follow-up

narrative review of obesity and its associated complications in Iranian women

Context: Obesity is a major public health problem worldwide. This review aimed at providing an updated overview of obesity in Iranian women and its associated complications

Evidence Acquisition: In this narrative review study, related systematic reviews or meta-analysis studies of high ranking journals conducted from 2000 to 2016 were searched in the PubMed, Medline, and Scopus with the following keywords: "women OR female" AND "weight OR overweight OR obesity", "risk factors OR complications", "reproduction OR cancer OR cardiovascular disease OR diabetes OR gestational diabetes OR maternal obesity OR fertility OR pregnancy OR polycystic ovary syndrome" OR management

Results: In Iran, women have shown a constantly higher risk of obesity compared to men. After a 9- year follow-up, the age-standardized incidence rate [95% CI] of diabetes was 10.1 [7.24 - 13.9] in women. The increases in overweight and obesity in menopausal women have an important role in endometrial, colon, and breast cancer. Obesity increases the risk of endometrial cancer 2.4 to 4.5 folds compared to the normal weight women. Maternal obesity increases the risk of gestational hypertension 4.5 to 8.7 times compared to normal weight women. An increasing number of obese women becoming pregnant is associated with short- and long-term maternal and child outcomes. The prevalence of childhood obesity in children of obese women aged 3 to 5 years increases up to 25%; and these children have an almost 6- fold chance of being obese in young adulthood. Weight reduction of obese women is accompanied with lower incidence of obesity complications. The most effective interventions are multiple behavioral management activities

Conclusions: Considering the large population of young people in Iran and the lack of any effective preventive policy, the burden of obesity and its associated outcomes will be problematic in the near future

association between dietary carbohydrate intake and pancreatic cancer risk: a large prospective study

Background: Pancreatic cancer [PC] is ranked as the 7th leading cause of cancer death worldwide and is one of the most deadly cancers. Several lines of evidence indicate that insulin resistance, diabetes, and obesity are implicated in its carcinogenesis

Materials and Methods: We examined the association between the consumption of carbohydrate foods and risk of PC in 50,045 participants [21241 men and 28804 women aged 40 to 75 years] of the Golestan Cohort Study in northeastern Iran. Dietary data were collected using a validated semi-quantitative food-frequency questionnaire. Cox proportional hazards models were used to estimate multivariate hazard ratio with 95% confidence interval

Results: During 8.5 years [383,630 person-years] of follow-up and after excluding participants with incomplete data, a total of 48,676 adults [20,683 men and 27,993 women] were studied. Until October 30, 2014, 54 cases of pancreatic cancer were confirmed by a medical team, based on the medical records and the exact cause of death according to ICD10 criteria. After adjusting for age, total energy intake, history of diabetes, smoking status, education, opium consumption, body mass index, waist to hip ratio, ethnicity, sex, the metabolic equivalent of task [MET], residential area, and socioeconomic status, we did not observe any statistically significant relationship between consumption of total carbohydrate and carbohydrate foods including whole grains, refined grains, sugars, and potatoes and risk of PC

Conclusion: Based on the results of the present study, dietary intake of total carbohydrate as well as various carbohydrate food sources had no significant association with the risk of PC. Finally, given the limited number of studies in this field and their inconclusive results, there is still a need for new prospective studies with long follow-up